| Shared resources |
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Here's a
list of resources used within EuReGene. If
you would
like more information, please click on the envelope-button
to email the involved
research group. |
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| Cell lines |
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Murine and human conditionally and stable transformed podocytes |
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Murine and human stable transformed mesangial cells |
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Murine stable transformed tubular cells |
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Murine stable transformed glomerular endothelial cells |
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Established proximal tubular cell
lines (LLC-PK1, OK cells). Unfortunately, these are a poor
model for the proximal tubule. |
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| Mouse lines |
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Obligate megalin knockout |
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Kidney-specific megalin knockout |
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Sortilin knockout |
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SorLA knockout |
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SorCS-2 knockout |
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| Mouse cre-lines |
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Podocin cre mice (podocyte specific gene excision, collaboration
LB Holzman) |
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ILK floxed mice |
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ApoE-Cre (kidney specific) |
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Meox-Cre (epiblast specific) |
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Mx-Cre (liver specific) |
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Osteocalcin Cre (bone specific) |
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| Resources |
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Gene expression signatures of all major human renal diseases |
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Podocyte and Podocyte –coculture systems |
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Extended set of real-time RT-PCR primer and probes for
glomerular cell lineage description (human and murine), podocyte
associated mRNAs |
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Bioinformatic tools: pathway mapping of array data, in
silico promoter modelling |
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Microarray data of renal transcriptome
of megalin KO mice |
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Microarray data of renal transcriptome
of normal mice, or animals treated with DDAVP or thirsted
animals |
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| Technologies |
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Real-time RT-PCR and array of microdissected glomeruli |
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Bioinformatics of gene expression profiles |
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In silico promoter modelling |
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Cell culture of lines described above |
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Expression profiling (Affymetrix technology) |
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Transgene technologies |
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Endocytosis assays in cultured cells |
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ISH |
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